Bionano Optical Genome Mapping (OGM) revolutionises genomic analysis by using single-molecule imaging based on long DNA fragments migration into nanochannels. This cutting-edge technology enables genome mapping with unprecedented precision, revealing structural variations, large-scale rearrangements and complex genomic profile. By providing comprehensive information on DNA organisation, Bionano’s platform enables a better understanding of genetic variations, improving the detection of genomic alterations.
Main applications
- Genomic research
- Detection of structural variations
- Understanding genetic diseases and variability
- Discovery of disease-causing mutations
- Enhances advances in precision medicine
Detection
- Structural rearrangements : translocation and inversion
- Copy number alterations : complete and partial gain and loss above 5Mb
Advantages
- High resolution
- Ability to map complex variations
- Exhaustive analysis of genomic rearrangements
Starting material
Cells, blood, bone marrow
Equipment
We use a Bionano Saphyr system.