Services > Non-Invasive Prenatal Testing (NIPT)


Non-Invasive Prenatal Testing (NIPT)

NIPT is a screening test that give information about the chance of having a baby with trisomy 21 (Down syndrome), trisomy 18 and trisomy 13.

This test has to be performed from 12 weeks of pregnancy. This test is a screening test, not a diagnostic one. In case of ultrasound abnormalities, a puncture of amniotic fluid has to be performed. In case of abnormal NIPT result, it would be confirmed by an amniocentesis.

Limitations

  •  The following conditions can affect the test precision: multiple pregnancy, woman with a chromosomal abnormality or overweight or history of cancer.

  • This test is not validated for detection of foetal mosaic chromosomal abnormality, foetal microdeletion/duplication or a monogenic disease (such as cystic fibrosis or X-fragile). However, if they are detected they will be reported.

  • The following conditions for the pregnant woman can affect the results: blood transfusion, transplantation, stem cell therapy due to the presence of circulating DNA from an origin different from the mother or foetus.

Performance

Chromosome differenceDetection rate
Trisomy 21
>98%
Trisomy 18
>97%
Trisomy 13
100%

Starting material

Placental DNA from blood sample

Kit and equipment

  • Modified commercial NextFlex™ kit (BIOO Scientific)
  • NextSeq and NovaSeq sequencers

Doctors and scientists can help you.

©   Seqalis™, a BIO.be company trademark - All rights reserved. Design by Oblique.