Services > Cytogenetics


SNP array

SNP array (SNPa) is a powerful technique that enables the analysis of specific genomic positions along the genome. These specific positions correspond to well-known single nucleotide polymorphism (SNP) located in clinically relevant regions associated with genetic disease and cancers. B-allele frequency is evaluate for each of these SNP and will determine their allelic status. This SNP coverage also enables detection of copy number alterations as small as 10 kb in regions associated with genetic disease.

Main applications and advantages

  • Possibility to screen the whole genome in a single analysis
  • High resolution in coding regions linked to human diseases and cancers
  • Adapted to genomic DNA and FFPE derived DNA·      
  • No DNA amplification needed (PCR-free technology)

Starting material

Blood, bone marrow, cells, fresh, frozen or FFPE tissue.

Detection

  • Chromosomal aberrations: complete and partial gain or loss above 5 Mb
  • Micro alterations: Gene(s) duplication or deletion

Equipment

High-resolution microarray (Infinium CytoSNP-850K BeadChip Array) analysed on NextSeq 550 scanner.

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