Shallow Whole Genome Sequencing (sWGS) is a high throughput sequencing technology that explores the entire genome to detect chromosomal imbalances (gain/loss). The quantity of fragments analysed for each region of the genome is compared to a reference pool of data obtained from normal samples. The region is considered as altered if the number of fragments is below (loss) or above (gain) the number of fragments in the reference.
Main applications and advantages
Possibility to screen the whole genome in an unique analysis
Capacity to process large batches of samples
Rapid, sensitive and automated technique
Resolution uniformity along the whole genome
Adapted to genomic DNA, circulating DNA and FFPE derived DNA